Phenotype, function and clinical implications of myeloid-derived suppressor cells in cancer patients

摘要: The involvement of a smouldering microenvironment is currently considered cancer hallmark and required step for tumour cells to disable specific immunity while promoting angiogenesis stroma remodelling. Nevertheless, the molecular pathways driving such aberrant interactions in human their actual implication disease progression are still poorly defined. Here, we will report about remarkable efforts devoted by our group as well many other scientists dissect this process focusing on tumour-mediated activation myeloid dysfunctional occurring patients. Indeed, myeloid-derived suppressor (MDSC), playing crucial role cellular regulators immune responses, have been extensively shown restrain through vast array mechanisms promote different murine models. Although mice phenotypic features these were defined initially rather generally Gr1+ CD11b+ co-expression, more recent studies unravelled complexity population existence cell subsets. This even remarked setting, where heterogeneous populations with variable phenotype immunosuppressive described patients affected types tumours. lack homogeneous properties MDSC has made controversial unacknowledged player cancer-related suppression progression. scientific community, soon reveal key thereby becoming novel targets innovative therapeutic strategies.