Inostamycin suppresses vascular endothelial growth factor-stimulated growth and migration of human umbilical vein endothelial cells
作者： Yuh Baba , Yasumasa Kato , Izumi Mochimatsu , Yoji Nagashima , Miki Kurihara
DOI: 10.1007/S10585-005-0041-0
关键词: Cyclin D1 、 Angiogenesis 、 Vascular endothelial growth factor 、 MAPK/ERK pathway 、 Umbilical vein 、 Chemistry 、 p38 mitogen-activated protein kinases 、 Vascular endothelial growth factor A 、 Kinase 、 Cell biology
摘要: Angiogenesis involves multiple steps including proliferation and migration of endothelial cells. In the present study, we determined effect inostamycin (an inhibitor phosphatidylinositol synthesis) on vascular growth factor (VEGF)-induced human umbilical vein cells (HUVECs). Inostamycin significantly attenuated both VEGF-induced HUVECs. inhibited activation mitogen-activated kinases (ERK p38) elevation cyclin D1 induced by VEGF. These data suggest that reduced HUVECs targeting ERK-cyclin p38, respectively.
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