Early‐life rotavirus and norovirus infections in relation to development of atopic manifestation in infants

摘要: Summary Background The increase in incidence of atopic diseases (ADs) the developed world over past decades has been associated with reduced exposure childhood infections. Objective To investigate relation between early intestinal viral infections to development symptoms (eczema, wheeze and sensitization) first second year(s) life. Methods In KOALA Birth Cohort Study, we assessed IgG seropositivity for rota- norovirus (GGI.1 GGII.4) at 1 year age. This was related allergic sensitization [specific immunoglobulin E (IgE)] 2 years, parent reported eczema using logistic regression analysis adjusted confounders. Results Rotavirus (39%) an unexpected higher risk recurrent life [adjusted odds ratio (OR) 3.1 95% confidence intervals (CI) 1.1–9.1] persistent new (adjusted OR 2.7 CI 1.1–6.2). No further associations were found manifestations. Conclusion Our data did not show a clear protection by enteric young children on IgE response allergens, but rotavirus infection factor wheeze. However, this needs be followed up older ages order establish true importance especially cumulative effects AD aetiology. Exposure may offer interesting focus infant later asthma development.