Working memory training decreases hippocampal neurogenesis.
作者： P. Mohapel , K. Mundt-Petersen , P. Brundin , H. Frielingsdorf
DOI: 10.1016/J.NEUROSCIENCE.2006.07.033
关键词: Working memory 、 Cognition 、 Psychology 、 Working memory training 、 Corticosterone 、 Neurogenesis 、 Hippocampal formation 、 Hippocampus 、 Morris water navigation task 、 Neuroscience
摘要: The relationship between adult hippocampal neurogenesis and cognition appears more complex than suggested by early reports. We aimed to determine if the duration task demands of spatial memory training differentially affect neurogenesis. Adult male rats were trained in Morris water maze a reference for 4 days, or alternatively working either 14 days. Four days did not impact regardless whether paradigms used. Interestingly, 2 weeks using hidden platform resulted fewer newborn neurons compared with controls that received cue no exposure. Stress is well-established negative regulator found general, particular, increased levels circulating corticosterone after training. Our study indicates over prolonged period time reduces neurogenesis, this reduction may partially be mediated stress.
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sci-hub.se 参考文章(15)
Elizabeth Gould, Anna Beylin, Patima Tanapat, Alison Reeves, Tracey J. Shors, Learning enhances adult neurogenesis in the hippocampal formation. Nature Neuroscience. ,vol. 2, pp. 260- 265 ,(1999) , 10.1038/6365
D. Ehninger, G. Kempermann, Paradoxical effects of learning the Morris water maze on adult hippocampal neurogenesis in mice may be explained by a combination of stress and physical activity Genes, Brain and Behavior. ,vol. 5, pp. 29- 39 ,(2005) , 10.1111/J.1601-183X.2005.00129.X
Henriette Van Praag, Gerd Kempermann, Fred H Gage, None, Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nature Neuroscience. ,vol. 2, pp. 266- 270 ,(1999) , 10.1038/6368
Jason Beiko, Rebecca Lander, Elizabeth Hampson, Francis Boon, Donald Peter Cain, Contribution of sex differences in the acute stress response to sex differences in water maze performance in the rat. Behavioural Brain Research. ,vol. 151, pp. 239- 253 ,(2004) , 10.1016/J.BBR.2003.08.019
Paul Mohapel, Christine T Ekdahl, Olle Lindvall, Status epilepticus severity influences the long-term outcome of neurogenesis in the adult dentate gyrus Neurobiology of Disease. ,vol. 15, pp. 196- 205 ,(2004) , 10.1016/J.NBD.2003.11.010
Argel Aguilar-Valles, Edith Sánchez, Patricia de Gortari, Israela Balderas, Víctor Ramírez-Amaya, Federico Bermúdez-Rattoni, Patricia Joseph-Bravo, Analysis of the Stress Response in Rats Trained in the Water-Maze: Differential Expression of Corticotropin-Releasing Hormone, CRH-R1, Glucocorticoid Receptors and Brain-Derived Neurotrophic Factor in Limbic Regions Neuroendocrinology. ,vol. 82, pp. 306- 319 ,(2005) , 10.1159/000093129
Radoslaw Rola, Jacob Raber, Angela Rizk, Shinji Otsuka, Scott R. VandenBerg, Duncan R. Morhardt, John R. Fike, Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice Experimental Neurology. ,vol. 188, pp. 316- 330 ,(2004) , 10.1016/J.EXPNEUROL.2004.05.005
Patrizia Ambrogini, Laura Orsini, Cecilia Mancini, Paola Ferri, Sandra Ciaroni, Riccardo Cuppini, Learning may reduce neurogenesis in adult rat dentate gyrus Neuroscience Letters. ,vol. 359, pp. 13- 16 ,(2004) , 10.1016/J.NEULET.2003.12.123
Paul Mohapel, Giampiero Leanza, Merab Kokaia, Olle Lindvall, Forebrain acetylcholine regulates adult hippocampal neurogenesis and learning. Neurobiology of Aging. ,vol. 26, pp. 939- 946 ,(2005) , 10.1016/J.NEUROBIOLAGING.2004.07.015
Patrizia Ambrogini, Riccardo Cuppini, Carla Cuppini, Sandra Ciaroni, Tiziana Cecchini, Paola Ferri, Stefano Sartini, Paolo Del Grande, Spatial learning affects immature granule cell survival in adult rat dentate gyrus Neuroscience Letters. ,vol. 286, pp. 21- 24 ,(2000) , 10.1016/S0304-3940(00)01074-0