When is adult hippocampal neurogenesis necessary for learning? evidence from animal research.

摘要: The hippocampus is a key brain structure involved in the shortand long-term processing of declarative memory. Since adult hippocampal neurogenesis was fi rst found, numerous studies have tried to establish contribution newborn neurons hippocampus-dependent cognitive functions. However, this large amount research has generated contradictory results. In paper, we review body evidence investigating relationship between and learning conclude functional role adult-born neurons. First, factors that could explain discrepancies among experiments are taken into account. Then, addition methodological differences, emphasize importance age studied, as how their maturation infl uences both properties potential functionality. Next, discuss which memory components require involvement neurogenesis, taking consideration representational demands task, its diffi culty level performance reached by subject. Finally, other modulate memory, such stress levels or previous experience animal, should also be interpreting focused on neurogenesis. conclusion, our analysis published suggests new neurons, under certain circumstances, crucial irreplaceable learning.