Value of fluoro-2-deoxy-D-glucose-positron emission tomography for detecting metastatic lesions in head and neck cancer.

摘要: OBJECTIVES The role of positron emission tomography (PET) scans in the staging head and neck cancer (HNC) is unclear. National Comprehensive Cancer Network guidelines do not recommend routine metastatic workup beyond physical examination, chest x-ray, laboratory tests. purpose this report to examine accuracy PET for detecting distant disease patients with HNC. METHODS Retrospective review 182 consecutive newly diagnosed HNC who had a scan at Thomas Jefferson University Hospital between 2003 2007. RESULTS overall incidence confirmed population was 5.0%. About 26 areas suspicious lesion(s). Of total, 23 were further evaluated imaging and/or biopsy, revealing 9 (39%) true positives, 14 (60%) false positives. 156 negative scans, there 1 155 negatives. Thus, sensitivity 90% specificity 92%. Positive predictive value 39% 99.4%. No pre-PET clinical stage I or II metastases. only statistically significant predictor IV versus all other stages (P=0.03). CONCLUSIONS Given marked differences treatment locally advanced/nonmetastatic HNC, we disease. Although sensitivity, specificity, rates acceptable, positive suboptimal. Patients found have "positive" require confirmatory ideally biopsy.