Quantitative techniques in 18FDG PET scanning in oncology.

作者: F Castell , G J R Cook

DOI: 10.1038/SJ.BJC.6604330

关键词: OncologyMedical physicsTreatment responseKinetic analysisClinical trialPositron emission tomography18fdg petInternal medicineMedicine

摘要: The clinical applications of 18F-fluoro-2-deoxyglucose (18FDG) positron emission tomography (PET) in oncology are becoming established. While simple static scanning techniques used for the majority routine examinations, increasing use PET trials to monitor treatment response with 18FDG and novel tracers reflecting different pharmacodynamic end points, often necessitates a more complex quantitative analysis radiopharmaceutical kinetics. A wide range exist, ranging from visual semiquantitative methods full dynamic studies kinetic analysis. These discussed, focusing particularly on available methodologies that can be utilised trials.

参考文章(32)
Tatsuo Ido, Kazuo Kubota, Roko Kubota, Susumu Yamada, Nobuaki Tamahashi, High accumulation of fluorine-18-fluorodeoxyglucose in turpentine-induced inflammatory tissue. The Journal of Nuclear Medicine. ,vol. 36, pp. 1301- 1306 ,(1995)
Antonia Dimitrakopoulou-Strauss, Volker Ewerbeck, Ludger Bernd, Ludwig G. Strauss, Cyrill Burger, Thomas Heichel, Hua Wu, The Role of Quantitative 18F-FDG PET Studies for the Differentiation of Malignant and Benign Bone Lesions The Journal of Nuclear Medicine. ,vol. 43, pp. 510- 518 ,(2002)
E. F. Patz, V. J. Lowe, J. M. Hoffman, R. E. Coleman, D. M. DeLong, Semiquantitative and visual analysis of FDG-PET images in pulmonary abnormalities. The Journal of Nuclear Medicine. ,vol. 35, pp. 1771- 1776 ,(1994)
Wolfgang A. Weber, Katja Ott, Karen Becker, Hans-Joachim Dittler, Hermann Helmberger, Norbert E. Avril, Günther Meisetschläger, Raymonde Busch, Jörg-Rüdiger Siewert, Markus Schwaiger, Ulrich Fink, Prediction of Response to Preoperative Chemotherapy in Adenocarcinomas of the Esophagogastric Junction by Metabolic Imaging Journal of Clinical Oncology. ,vol. 19, pp. 3058- 3065 ,(2001) , 10.1200/JCO.2001.19.12.3058
Marc Hickeson, Alexander Matthies, Abass Alavi, Andrew Cuchiara, Dual Time Point 18F-FDG PET for the Evaluation of Pulmonary Nodules The Journal of Nuclear Medicine. ,vol. 43, pp. 871- 875 ,(2002)
Antonia Dimitrakopoulou-Strauss, Ludwig G. Strauss, Frank Willeke, Thomas Lehnert, Cyrill Burger, Gunhild Mechtersheimer, Matthias Schwarzbach, Thomas Heichel, Dynamic PET 18F-FDG Studies in Patients with Primary and Recurrent Soft-Tissue Sarcomas: Impact on Diagnosis and Correlation with Grading The Journal of Nuclear Medicine. ,vol. 42, pp. 713- 720 ,(2001)
Wolfgang A Weber, Use of PET for Monitoring Cancer Therapy and for Predicting Outcome The Journal of Nuclear Medicine. ,vol. 46, pp. 983- 995 ,(2005)
V J Lowe, J W Fletcher, L Gobar, M Lawson, P Kirchner, P Valk, J Karis, K Hubner, D Delbeke, E V Heiberg, E F Patz, R E Coleman, Prospective investigation of positron emission tomography in lung nodules. Journal of Clinical Oncology. ,vol. 16, pp. 1075- 1084 ,(1998) , 10.1200/JCO.1998.16.3.1075
Antoon Willemsen, Jorg Hoff, Fundamentals of quantitative PET data analysis. Current Pharmaceutical Design. ,vol. 8, pp. 1513- 1526 ,(2002) , 10.2174/1381612023394359