Mitochondrial DNA targeting and impairment by a dinuclear Ir–Pt complex that overcomes cisplatin resistance
作者： Cheng Zhang , Ruilin Guan , Xinxing Liao , Cheng Ouyang , Jiangping Liu
DOI: 10.1039/D0QI00224K
关键词: Mechanism of action 、 MTT assay 、 Chemistry 、 Nuclear DNA 、 Molecular biology 、 Programmed cell death 、 Caspase 3 、 Apoptosis 、 Cancer cell 、 Mitochondrial DNA
摘要: … mtDNA is the expected target of Ir–Pt, we further evaluated the selectivity of Ir–Pt towards mtDNA… polymerase chain reaction) of mitochondrial and nuclear DNA damage were performed. …
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