Sulfadimidine Acetylation in Norwegians
作者： Harald Olsen , Jørg Mørland
DOI: 10.1111/J.0954-6820.1981.TB09786.X
关键词: Medicine 、 Animal science 、 Sulfadimidine 、 Acetylator phenotype 、 Healthy volunteers 、 Internal medicine
摘要: The acetylation of sulfadimidine was studied in 152 healthy volunteers (29 Lapps, 73 Norwegians and 50 South Norwegians) by means fraction acetylated drug half-life. distribution rapid acetylators different among Lapps (72%) (44%) (p less than 0.01). North resembled the Norwegians, but some regional approach to Lappish pattern found. Great interindividual differences half-lives were demonstrated. mean half-life (+/- S.E.M.) 384 +/- 17 min slow 148 8 acetylators. Among participants with 420 intraindividual correlation bimodal while suggested be trimodal.
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