Dynamic of plasmodium falciparum chloroquine resistance transporter gene Pfcrt K76T mutation five years after withdrawal of chloroquine in Burkina Faso.
作者： Paul Sondo , Karim Derra , Zekiba Tarnagda , Seydou Diallo Nakanabo , Odile Zampa
DOI: 10.11604/PAMJ.2015.21.101.6437
关键词: Malaria 、 Chloroquine 、 Mutant 、 Drug resistance 、 Plasmodium falciparum 、 Virology 、 Allele 、 Medicine 、 Wild type 、 Single-nucleotide polymorphism
摘要: We investigated the evolution of Pfcrt K76T mutation five years after withdrawal chloroquine in Burkina Faso. A total 675 clinical isolates collected from October 2010 to September 2012 were successfully genotyped. Single nucleotide polymorphism (codon 76) gene was analyzed. The prevalence resistant 76T allele 20.55%. There a progressive decrease proportion mutant type pfcrt T76 (X2=5.508 p=0.0189). Our results suggest return wild K76 Faso but mutants still remains high.
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