Comprehensive characterization of chemotherapeutic efficacy on metastases in the established gastric neuroendocrine cancer patient derived xenograft model.
作者： Jiahua Jiang , Daisy Dandan Wang , Mengmeng Yang , Dawei Chen , Liang Pang
关键词: Vascular endothelial growth factor B 、 Cisplatin 、 Circulating tumor cell 、 Primary tumor 、 Cytokeratin 、 Metastasis 、 Pathology 、 Gastric Neuroendocrine Carcinoma 、 Biology 、 Context (language use)
摘要: The HuPrime® human gastric neuroendocrine carcinoma derived xenograft model GA0087 was established in this study. PDX showed high gene expression of vascular endothelial growth factors (VEGF)-A and B, potential lung metastasis. Circulating tumor cells (CTCs) with either large or small size, circulating microemboli (CTM) metastatic lesions were detected mice. number CTC correlated to the nodules lung. Both primary metastasis terms dynamically monitored CTCs effectively suppressed by Cisplatin. Diverse subtypes context sensitivity Cisplatin specifically identified subtraction enrichment (SE) integrated situ Phenotyping cytokeratin 18 (CK18) Karyotyping chromosome 8 (in PK CK-iFISH). All CK18-/diploid majority CK18+/diploid chemosensitive, whereas a higher percentage CK18+/multiploid subtype Cisplatin-insensitive. Combined histopathological examination lesion (mPDX) are particular significance, may provide an unique robust platform for cancer research as well pre-clinical evaluation therapeutic efficacy new anti-cancer drugs.
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