Response of Patient-Derived Non-Small Cell Lung Cancer Xenografts to Classical and Targeted Therapies Is Not Related to Multidrug Resistance Markers

摘要: Tumor cells that are nonsensitive to anticancer drugs frequently have a multidrug resistant (MDR) phenotype. Many studies with cell lines and patient material been done investigate the impact of different resistance markers at protein mRNA level in drug but contradictory outcome. In present study, 26 well-characterised patient-derived non-small lung cancer xenografts were used. The known chemosensitivity etoposide, carboplatin, gemcitabine, paclitaxel erlotinib was compared expression BCRP, LRP, MDR1, MRP1. Further, four these short-term treated analyse possible regulation mechanisms after therapeutic interventions. We found borderline correlation between bcrp response etoposide. All other constitutive levels not correlated any significantly influenced by short term treatment. results indicate MDR proteins investigated do play an important role chemoresistance NSCLC vivo situation.