Expression of Multidrug Resistance Proteins and Accumulation of Cisplatin in Human Non-small Cell Lung Cancer Cells
作者： Kenji Ikuta , Kazu Takemura , Kenichi Sasaki , Masaru Kihara , Masuhiro Nishimura
DOI: 10.1248/BPB.28.707
关键词:
摘要: In order to understand and overcome multidrug resistance (MDR) of human non-small cell lung cancer (NSCLC), mRNA protein expression levels P-glycoprotein (MDR1), resistance-associated 1 (MRP1), resistance-related (LRP) were investigated compared with the chemosensitivity intracellular/intranuclear cisplatin accumulation three NSCLC lines (Ma-10, Ma-31, Ma-46). Ma-31 was more resistant than Ma-10 Ma-46 cisplatin, carboplatin, etoposide, paclitaxel. The level MDR1 extremely low, not detected in all lines. MRP1 highest lowest Ma-10, but there no notable difference between LRP mRNA/protein equally expressed nominal Ma-46. cells determined be Ma-31>Ma-46>Ma-10. Thus, MDR1, MRP1, correlated or each line. present results indicate that MDR proteins (MDR1, LRP) may play an important role chemoresistance drug efflux cells.
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