Platinum transporters and drug resistance
作者： Min-Koo Choi , Dae-Duk Kim
DOI: 10.1007/BF02969293
关键词:
摘要: Cisplatin, a platinum coordinated complex, is widely used antineoplastic agent for the treatment of metastatic tumors testis, ovarian tumors, lung cancer, advanced bladder cancer and many other solid tumors. The cytotoxic action drug often thought to be associated with its ability bind DNA form cisplatin-DNA adducts. development resistance cisplatin during common constitutes major obstacle cure sensitive Although understand clinically relevant mechanisms resistance, studies have been aimed at clarifying biochemical/molecular alterations cisplatin-resistance cells, these did not conclusively identify basis cellular cisplatin. In this review, was discussed in terms transporters, such as copper transporters (CTRs), organic cation (OCTs) multi-drug related (MDRs). These seem contributed through reduction accumulation cell. Better understanding mechanism will provide useful informations overcoming resistance.
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