Oncotype DX tumor gene expression profiling in stage II colon cancer. Application: prognostic, risk prediction.

作者: Elizabeth M. Webber , Jennifer S. Lin , Evelyn P. Whitlock

DOI: 10.1371/CURRENTS.RRN1177

关键词: Risk stratificationDiseaseStage ii colon cancerColorectal cancerOncotype DXOncologyGene expression profilingGynecologyInternal medicineMedicine

摘要: Overall five-year survival for patients with stage-II colon cancer averages 75% after surgery alone. However, some of these have poorer outcomes, similar to stage-III disease. The proposed use the Oncotype DX assay is improve risk stratification recurrence in cancer. Abstract

参考文章(5)
D. Kerr, R. Gray, P. Quirke, D. Watson, G. Yothers, I. C. Lavery, M. Lee, M. J. O’Connell, S. Shak, N. Wolmark, , A quantitative multigene RT-PCR assay for prediction of recurrence in stage II colon cancer: Selection of the genes in four large studies and results of the independent, prospectively designed QUASAR validation study Journal of Clinical Oncology. ,vol. 27, pp. 4000- 4000 ,(2009) , 10.1200/JCO.2009.27.15_SUPPL.4000
Alvaro Figueredo, Megan E Coombes, Som Mukherjee, ADJUVANT THERAPY FOR COMPLETELY RESECTED STAGE II COLON CANCER Cochrane Database of Systematic Reviews. ,vol. 3, pp. 5390- 5390 ,(2008) , 10.1002/14651858.CD005390.PUB2
Kakil Ibrahim Rasul, David J. Kerr, QUASAR Results: The Prognostic Validity of a Colon Cancer Recurrence Score and the Role of Multigene Profiles in Determining Risk Current Colorectal Cancer Reports. ,vol. 6, pp. 144- 147 ,(2010) , 10.1007/S11888-010-0053-2
Kim M Clark-Langone, Jenny Y Wu, Chithra Sangli, Angela Chen, James L Snable, Anhthu Nguyen, James R Hackett, Joffre Baker, Greg Yothers, Chungyeul Kim, Maureen T Cronin, Biomarker discovery for colon cancer using a 761 gene RT-PCR assay BMC Genomics. ,vol. 8, pp. 279- 279 ,(2007) , 10.1186/1471-2164-8-279
M. J. O'Connell, I. C. Lavery, R. G. Gray, P. Quirke, D. J. Kerr, M. Lopatin, G. A. Yothers, M. Lee, K. Clark-Langone, N. Wolmark, Comparison of molecular and pathologic features of stage II and stage III colon cancer in four large studies conducted for development of the 12-gene colon cancer recurrence score. Journal of Clinical Oncology. ,vol. 28, pp. 3503- 3503 ,(2010) , 10.1200/JCO.2010.28.15_SUPPL.3503