Testosterone is more effective than dihydrotestosterone plus estradiol in activating sexual behavior in old male rats.
作者： Kathleen C. Chambers , Charles H. Phoenix
DOI: 10.1016/0197-4580(86)90151-X
关键词: Endocrinology 、 Testosterone propionate 、 Senescence 、 Medicine 、 Male rats 、 Sexual behavior 、 Hormone 、 Dihydrotestosterone 、 Estradiol benzoate 、 Testosterone 、 Internal medicine
摘要: Abstract Sexual behavior declines in old male rats, and testosterone therapy does not restore the to levels found young males. If as a result of aging, males have less capacity aromatize or reduce testosterone, dihydrotestosterone plus estradiol treatment should be more effective than restoring sexual castrated In test this hypothesis, (24 months) Fischer 344 given injections propionate (TP) (DHTP) benzoate (EB) that sham-operated vehicle were observed. The DHTP/EB proved overall TP increasing second experiment, (3 (30 tested verify reduced effectiveness was age-related. Testosterone equally most measures no these same measures. Neither hormone increased level Since is stimulating males, likely explanation for decreased responsiveness rats.
sci-hub.se 参考文章(21)
C. H. Phoenix, K. C. Chambers, Sexual Behavior in Aging Male Rhesus Monkeys Proceedings in Life Sciences. pp. 95- 104 ,(1982) , 10.1007/978-3-642-68300-8_8
B. D. Sachs, Potency and Fertility: Hormonal and Mechanical Causes and Effects of Penile Actions in Rats Springer, Berlin, Heidelberg. pp. 86- 110 ,(1983) , 10.1007/978-3-642-69216-1_7
C Beyer, G Morali, F Naftolin, K Larsson, G Perez-Palacios, Effect of some antiestrogens and aromatase inhibitors on androgen induced sexual behavior in castrated male rats Hormones and Behavior. ,vol. 7, pp. 353- 363 ,(1976) , 10.1016/0018-506X(76)90040-4
Concetta Lupo-di Prisco, Francesco Dessi-Fulgheri, Endocrine and Behavioral Modifications in Aging Male Rats Hormone Research in Paediatrics. ,vol. 12, pp. 149- 160 ,(1980) , 10.1159/000179116
Kathleen C. Chambers, Charles H. Phoenix, Sexual behavior in old male rhesus monkeys: Influence of familiarity and age of female partners Archives of Sexual Behavior. ,vol. 11, pp. 299- 308 ,(1982) , 10.1007/BF01541591
Kathleen C. Chambers, Charles H. Phoenix, Testosterone and the decline of sexual behavior in aging male rats Behavioral and Neural Biology. ,vol. 40, pp. 87- 97 ,(1984) , 10.1016/S0163-1047(84)90194-8
C.H. Phoenix, K.H. Copenhaver, R.M. Brenner, Scanning electron microscopy of penile papillae in intact and castrated rats Hormones and Behavior. ,vol. 7, pp. 217- 227 ,(1976) , 10.1016/0018-506X(76)90049-0
Donald C Paup, Stewart P Mennin, Roger A Gorski, Androgen- and estrogen-induced copulatory behavior and inhibition of luteinizing hormone (LH) secretion in the male rat Hormones and Behavior. ,vol. 6, pp. 35- 46 ,(1975) , 10.1016/0018-506X(75)90021-5
Pauline Yahr, Data and hypotheses in tales of dihydrotestosterone. Hormones and Behavior. ,vol. 13, pp. 92- 96 ,(1979) , 10.1016/0018-506X(79)90037-0
K Larsson, P Södersten, C Beyer, Sexual behavior in male rats treated with estrogen in combination with dihydrotestosterone Hormones and Behavior. ,vol. 4, pp. 289- 299 ,(1973) , 10.1016/0018-506X(73)90028-7