Spaceflight effects on T lymphocyte distribution, function and gene expression

作者: Daila S. Gridley , James M. Slater , Xian Luo-Owen , Asma Rizvi , Stephen K. Chapes

DOI: 10.1152/JAPPLPHYSIOL.91126.2008

关键词: ImmunologyRegulation of gene expressionGene expression profilingImmune systemSpleenBiologyGene expressionSpaceflightWeightlessnessT lymphocyte

摘要: The immune system is highly sensitive to stressors present during spaceflight. major emphasis of this study was on the T lymphocytes in C57BL/6NTac mice after return from a 13-day space shuttle...

参考文章(87)
G. R. Taylor, J. R. Dardano, L. S. Neale, Immunological analyses of U.S. Space Shuttle crewmembers. Aviation, Space, and Environmental Medicine. ,vol. 57, pp. 213- 217 ,(1986)
Raymond P Stowe, Duane L Pierson, Clarence F Sams, Effects of mission duration on neuroimmune responses in astronauts. Aviation, Space, and Environmental Medicine. ,vol. 74, pp. 1281- 1284 ,(2003)
Mark Lyte, Cheryl L. Gould, Adrian D. Mandel, Joann Williams, Gerald Sonnenfeld, Inhibited interferon-gamma but normal interleukin-3 production from rats flown on the space shuttle. Aviation, Space, and Environmental Medicine. ,vol. 58, pp. 983- 986 ,(1987)
Stephen Keith Chapes, Lessons from Immune 1-3: what did we learn and what do we need to do in the future? Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology. ,vol. 11, pp. 45- ,(2004)
D S Gridley, M J Pecaut, G A Nelson, Dose and dose rate effects of whole-body gamma-irradiation: I. Lymphocytes and lymphoid organs in Vivo. ,vol. 15, pp. 195- 208 ,(2001)
Michael J. Pecaut, Gregory A. Nelson, Luanne L. Peters, Paul J. Kostenuik, Ted A. Bateman, Sean Morony, Louis S. Stodieck, David L. Lacey, Steven J. Simske, Daila S. Gridley, Genetic models in applied physiology: selected contribution: effects of spaceflight on immunity in the C57BL/6 mouse. I. Immune population distributions Journal of Applied Physiology. ,vol. 94, pp. 2085- 2094 ,(2003) , 10.1152/JAPPLPHYSIOL.01052.2002
Daila S. Gridley, Gregory A. Nelson, Luanne L. Peters, Paul J. Kostenuik, Ted A. Bateman, Sean Morony, Louis S. Stodieck, David L. Lacey, Steven J. Simske, Michael J. Pecaut, Genetic models in applied physiology: selected contribution: effects of spaceflight on immunity in the C57BL/6 mouse. II. Activation, cytokines, erythrocytes, and platelets Journal of Applied Physiology. ,vol. 94, pp. 2095- 2103 ,(2003) , 10.1152/JAPPLPHYSIOL.01053.2002
G. Sonnenfeld, A. D. Mandel, I. V. Konstantinova, W. D. Berry, G. R. Taylor, A. T. Lesnyak, B. B. Fuchs, A. L. Rakhmilevich, Spaceflight alters immune cell function and distribution Journal of Applied Physiology. ,vol. 73, ,(1992) , 10.1152/JAPPL.1992.73.2.S191
B. B. Hashemi, J. E. Penkala, C. Vens, H. Huls, M. Cubbage, C. F. Sams, T cell activation responses are differentially regulated during clinorotation and in spaceflight The FASEB Journal. ,vol. 13, pp. 2071- 2082 ,(1999) , 10.1096/FASEBJ.13.14.2071
ALAN Y. W. LEE, STEPHEN S. M. CHUNG, Contributions of polyol pathway to oxidative stress in diabetic cataract The FASEB Journal. ,vol. 13, pp. 23- 30 ,(1999) , 10.1096/FASEBJ.13.1.23