Photosensitized inactivation of Chinese hamster cells by phthalocyanines.

摘要: Chloroaluminum phthalocyanine was found to sensitize cultured Chinese hamster cells upon exposure white fluorescent light. Elimination of wavelengths below 370 nm did not reduce the effect significantly, indicating that effective were those absorbed by Q band (600–700 nm) phthalocyanine. The magnitude photosensitizing increased with dye concentration and time its contact prior light exposure. Although photosensitization drastically reduced in absence oxygen, lack glycerol D20 during suggests neither hydroxyl radicals nor 1O2 are responsible for cytotoxic response. efficiency photosensitized induced cell killing vary position cycle, contrast X-rays. improved spectral properties, reported low toxicity selective retention neoplasms, make phthalocyanines promising candidates use photodynamic therapy cancer.