Photoradiation therapy and its potential in the management of neurological tumors.

摘要: ✓ Photoradiation therapy is a form of local treatment that depends on the selective retention photosensitizer, such as hematoporphyrin derivative (HpD), by tumor followed with light an appropriate wavelength to activate sensitizer in tumor. The uptake HpD cerebral tumors has been demonstrated both laboratory animal model studies and clinical studies, destruction intracerebral glioma models. biological basis for photoradiation and, particular, mechanisms into are discussed. Current evidence suggests singlet oxygen major intermediary leading cell damage, although other radicals hydrogen peroxide hydroxyl may be involved. Other suggest initial damage blood vessels, subsequently undergoes ischemic ...