New Sensitizers for Photodynamic Therapy of Cancer
作者： Johan E. van Lier
DOI: 10.1007/978-1-4613-0709-9_18
关键词:
摘要: The sensitizer preparations currently used in clinical trials of photodynamic therapy (PDT) cancer (Dougherty, 1987) consist mixtures hematoporphyrin derivatives (HPD) obtained via alkaline hydrolysis acetates (Lipson et al., 1961; Bonnett 1981). Although the different components HPD all exhibit good vitro properties, only aggregated fraction is sufficiently retained by neoplasms to vivo action. This active component has been labeled DHE and characterized as a mixture dihematoporphyrins oligomers containing 2–5 (HP) units (Kessel, linked ether ester bonds (Dougherty 1984; Kessel, 1986a). It recently shown Kessel (1987) that both material localizes tumors furthermore, upon storage occurs resulting enrichment hematoporphy- rins fraction. In view increased understanding chemical nature several attempts have made rationalize preparation DHE. development photosensitizers with improved photochemical.properties also actively pursued. Hematoporphyrins absorb weakly above 600 nm (Fig. 1), where light exhibits optimal penetration through tissue, porphin analogs re-shifted absorption maxima compared are at present under evaluation alternative for PDT.
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