Pulsatile growth hormone secretion in normal man during a continuous 24-hour infusion of human growth hormone releasing factor (1-40). Evidence for intermittent somatostatin secretion.

摘要: Growth hormone (GH) secretory patterns were studied in a patient with ectopic growth releasing factor (GRF) secretion and normal men given continuous infusions of human (1-40)-OH (hGRF-40). In the GRF secretion, GH was pulsatile despite continuously elevated immunoreactive levels. To determine if is maintained subjects, we administered to six healthy young vehicle or hGRF-40, 2 ng/kg per min, for 24 h gave supramaximal intravenous bolus dose 3.3 micrograms/kg, after 23.5 infusion. hGRF-40 infusion resulted greater than did throughout During infusion, total (microgram; mean +/- SEM) 634 151 compared 1,576 284 during (P = 0.042). The response infusion; 877 170 386 125 micrograms secreted on days, respectively 0.015). amount 25.5 two study days not different; 1,504 260 1,952 383 0.36). Not only but there augmentation naturally occurring pulses, which contrast effect gonadotropin-releasing gonadotropin secretion. We suggest that pulses are result associated diminution withdrawal somatostatin