Proteomic approaches for drug discovery against tegumentary leishmaniasis

摘要: Abstract Tegumentary leishmaniases (TL) comprise various clinical forms, in which current therapeutic treatments lack safety and efficacy. Recently the parasite is developing resistance mechanisms against anti leishmanial drugs startling scientific community to recruit efforts search for novel therapeutics. Proteomics hold promises treatment of leishmaniasis investigation parasite–host interaction since these set methodological tools have provided a wealth protein expression data on several Leishmania species. Firstly this review puts together challenges fight tegumentary leishmaniasis. In addition, 2 dimensional gel electrophoresis mass spectrometry techniques identification characterization are described discussed context proteomics regarding studies. review, we selected literature content TL causative agents. Important proteomic findings related differentiation proteome (promastigote amastigote forms), -macrophage secreted soluble proteins including molecules involved potential drug targets examined discussed. We also highlight open questions research that can be addressed with approaches.