N-cadherin is Required for Cytodifferentiation during Zebrafish Odontogenesis

摘要: N-cadherin is a well-studied classic cadherin involved in multiple developmental processes and also known to have signaling function. Using the zebrafish (Danio rerio) as model, we tested hypothesis that tooth morphogenesis accompanied by dynamic changes distribution absence of disturbs development. N-cadherin, encoded gene cdh2, absent during initiation stages both primary (first-generation) replacement teeth, demonstrated immunohistochemistry. However, up-regulated at onset differentiation cells inner dental epithelium papilla, i.e., ameloblasts odontoblasts, respectively. In epithelium, co-expressed with E-cadherin, excluding occurrence switching such observed human While early lethality knockout mice prevents any functional study mouse odontogenesis, parachute (pac) mutants, deficient for survive beyond age when teeth normally start form. these first forms, but its development stops cytodifferentiation stage. deficiency completely inhibits other first-generation possibly due once has differentiated.