Distribution of Systemically Administered Nanoparticles Reveals a Size-Dependent Effect Immediately following Cardiac Ischaemia-Reperfusion Injury.
作者： David J. Lundy , Kun-Hung Chen , Elsie K.-W. Toh , Patrick C.-H. Hsieh
DOI: 10.1038/SREP25613
关键词: Chemistry 、 Nanoparticle 、 Ventricle 、 Biodistribution 、 Myocardial infarction 、 Cardiac ischaemia 、 Size dependent 、 Pharmacology 、 Distribution (pharmacology) 、 Surgery 、 Reperfusion injury
摘要: Nanoparticles represent an attractive option for systemic delivery of therapeutic compounds to the heart following myocardial infarction. However, it is well known that physicochemical properties nanoparticles such as size, shape and surface modifications can vastly alter distribution uptake injected nanoparticles. Therefore, we aimed provide examination rapid size-dependent fluorescent PEG-modified polystyrene administered immediately cardiac ischaemia-reperfusion injury in mice. By assessing biodistribution with core diameters between 20 nm 2 μm 30 minutes after their administration, conclude 20–200 nm diameter are optimal passive targeting injured left ventricle.
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