Zinc sulfate as an adjunct to methylphenidate for the treatment of attention deficit hyperactivity disorder in children: A double blind and randomized trial [ISRCTN64132371]

摘要: Attention-deficit hyperactivity disorder is an early-onset, clinically heterogenous of inattention, hyperactivity, and impulsiveness. The diagnosis treatment attention-deficit continues to raise controversy, and, there also increase in options. In this 6-week double blind, placebo controlled-trial, we assessed the effects zinc plus methylphenidate children with attention deficit disorder. To best our knowledge, study first blind controlled clinical trial assessing adjunctive role ADHD. Our subjects were 44 outpatient (26 boys 18 girls) between ages 5–11 (mean ± SD was 7.88 1.67) who clearly met DSM IV diagnostic criteria for they randomized 1 mg/kg/day + sulfate 55 mg/day (with approximately 15 mg element) (group 1) (sucrose mg) 2) a 6 week trial. principal measure outcome Teacher Parent ADHD Rating Scale. Patients by child psychiatrist at baseline, 14, 28 42 days after medication started. present shows Scale scores improved over 6-week, behavior two treatments not homogeneous across time. difference protocols significant as indicated effect on group, between-subjects factor (F = 4.15, d.f. 1, P 0.04; F 4.50, 0.04 respectively). groups frequency side significant. This double-blind, placebo-controlled demonstrated that supplementary might be beneficial However, further investigations different doses are required replicate these findings