HALF-DOSE PHOTODYNAMIC THERAPY COMBINED WITH BEVACIZUMAB FOR POLYPOIDAL CHOROIDAL VASCULOPATHY.

摘要: PURPOSE To evaluate the efficacy of half-dose photodynamic therapy (PDT) combined with intravitreal bevacizumab (IVB) for polypoidal choroidal vasculopathy. METHODS For this retrospective comparative study, data from 57 patients (63 eyes) at least 12 months follow-up were reviewed. Full-dose or PDT a single IVB treatment was performed according to time period. From 3 after initial combination treatment, retreatment mainly using anti-vascular endothelial growth factor injections on an as-needed basis. RESULTS Consecutively, 33 eyes treated full-dose PDT/IVB and 30 PDT/IVB. At Month 3, induced negligible damage physiologic choroid but inferior in achieving complete polyp closure (43.3% vs. 72.7%, P = 0.018) improving mean best-corrected visual acuity (20/66 20/43, 0.020). 12, group achieved comparable improvement (20/51 20/40, 0.254) required more additional (a 2.80 1.03, 0.004). CONCLUSION Despite inducing closure, followed by showed promising outcomes while avoiding choroid. Further long-term study is needed plus