One-Year Results of Reduced-Fluence Photodynamic Therapy for Polypoidal Choroidal Vasculopathy

摘要: Purpose To report 1-year results of reduced-fluence photodynamic therapy (PDT) for polypoidal choroidal vasculopathy (PCV) in Japanese patients. Design Prospective interventional case series. Methods In the present study, 28 treatment-naive eyes consecutive patients underwent PDT with a reduced laser fluence 25 J/cm 2 . Patients were followed up at baseline and 1 week 3, 6, 9, 12 months after PDT. Choroidal perfusion changes evaluated by indocyanine green angiography (ICGA) leakage from PCV lesions exudative fluorescein optical coherence tomography. Treatment safety was assessed according to visual acuity (VA) adverse events. The best-corrected VA (BCVA) obtained Landolt ring tests converted into logarithm minimal angle resolution (logMAR). Results At baseline, mean logMAR BCVA 0.45 (geometric mean: 7/20). months, significantly improved 0.29 10/20) ( P = 0.0001). stable or ≥0.2 26 (93%) follow-up. 10 better than 20/40 compared months. Although 16 (57%) showed mild moderate nonperfusion choriocapillaris early ICGA week, 27 (96%) recovery pretreatment levels 3 Mean number treatment sessions during 1.3. No severe side effects related encountered. Conclusions Reduced-fluence is an effective could improve vision even 20/40.