Immature CD45RA(low)RO(low) T cells in the human cord blood. I. Antecedents of CD45RA+ unprimed T cells.

摘要: A subset of resting T cells expressing low levels CD45RA and CD45RO molecules ( 90% CD45RA(low)RO(low) showed only transient expression rapidly acquired reactivity. After activation for 48 h the stimulated synthesized high IL-2, comparable to mature peripheral cells. No IL-4 was detected in these cultures cord blood These data taken together suggest that are relatively immature antecedents CD45RA+RO require stromal factors survival a state. The same need monocytes or IL-1 their develop after short CD45RA+ stage into activated CD45RO+RA(low) with potent IL-2 biosynthetic capacity. An additional study is warranted confirm they fact recent emigrants from thymus, as suggested by similar observations animal models.