Thyrotropin-releasing hormone (TRH) modifies oxytocin release from the hypothalamo-neurohypophysial system in salt-loaded rats.

摘要: Rats drinking ad libitum tap water or hypertonic (i.e. 2%) sodium chloride solution were given intracerebroventricularly (i.c.v.), for three days, thyrotropin-releasing hormone (TRH) in a daily dose of 200 ng dissolved 10 microliters 0.9% chloride. Treatment with TRH resulted significantly decreased hypothalamic oxytocin content both euhydrated libitum) and salt-loaded rats. In rats water, neurohypophysial decreased. Plasma concentration was distinctly elevated under treatment but, on the contrary, as compared animals similarly saline but not TRH-treated. The present data suggest that may be involved some regulatory processes related to biosynthesis release from rat hypothalamo-neurohypophysial system.