Pharmacological Intervention to Modulate HDL: What Do We Target?

摘要: The cholesterol concentrations of low-density lipoprotein (LDL) and high-density (HDL) have traditionally served as risk factors for cardiovascular disease. As such, novel therapeutic interventions aiming to raise HDL been tested in the clinical setting. However, most trials led a significant increase with no improvement events. complexity particle, which exerts multiple physiological functions is comprised number subclasses, has raised question whether there should be more focus on subclass function rather than quantity. We review current data regarding subclasses subclass-specific functionality highlight how lipid modifying drugs such statins, cholesteryl ester transfer protein inhibitors, fibrates niacin often specific subclasses. In addition this sets out arguments suggesting that HDL3 may provide better protective effects HDL2.