Molecular susceptibility weighted imaging of the glioma rim in a mouse model.

作者: Barbara Blasiak , James Landry , Randy Tyson , Jonathan Sharp , Umar Iqbal

DOI: 10.1016/J.JNEUMETH.2014.01.034

关键词: MRI contrast agentNuclear magnetic resonanceMagnetic resonance imagingSusceptibility weighted imagingPulse sequenceNuclear medicineMolecular imagingGadoliniumGliomaSurgical planningMedicine

摘要: Abstract Background Glioma is the most common and difficult to treat brain cancer. Despite many efforts treatment, efficacy remains low. As neurosurgical removal standard procedure for glioma, a method, allowing both early detection exact determination of location, size extent tumor, could improve patient's positive response therapy. New method We propose application susceptibility weighted molecular magnetic resonance imaging using, targeted contrast agents, based on superparamagnetic iron oxide nanoparticles, the, glioma rim, namely brain-tumor interface. Iron attached cells increases, differences at boundary between tumor normal tissue, providing opportunity, utilize improved delineation. investigated potential, enhancement tumor-brain contrast, including core rim when using susceptibility, MRI glioma. Results There were significant in contrast-to-noise ratio before, 12 120 min after agent injection gradient echo pulse sequence molecular, core-brain, rim-core rim-brain areas. Comparison with existing methods Currently, used diagnosis non-specific, gadolinium-based T1-weighted enhancement. Susceptibility-weighted magnetic, much less efficient no agents are, used. Conclusion The provided by SWI offers an important new tool for, surgical planning.

参考文章(44)
Silun Wang, Jinyuan Zhou, Diffusion Tensor Magnetic Resonance Imaging of Rat Glioma Models Journal of Computer Assisted Tomography. ,vol. 36, pp. 739- 744 ,(2012) , 10.1097/RCT.0B013E3182685436
Hiroko Ohgaki, Paul Kleihues, Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendroglial gliomas. Journal of Neuropathology and Experimental Neurology. ,vol. 64, pp. 479- 489 ,(2005) , 10.1093/JNEN/64.6.479
Juliana Hamzah, Joseph G. Altin, Thomas Herringson, Christopher R. Parish, Günter J. Hämmerling, Helen O'Donoghue, Ruth Ganss, Targeted Liposomal Delivery of TLR9 Ligands Activates Spontaneous Antitumor Immunity in an Autochthonous Cancer Model Journal of Immunology. ,vol. 183, pp. 1091- 1098 ,(2009) , 10.4049/JIMMUNOL.0900736
Wei Jiang, Cunli Xiang, Simona Cazacu, Chaya Brodie, Tom Mikkelsen, Insulin-like Growth Factor Binding Protein 7 Mediates Glioma Cell Growth and Migration Neoplasia. ,vol. 10, pp. 1335- 1342 ,(2008) , 10.1593/NEO.08694
Weili Lin, Pratik Mukherjee, Myeong S. Yoon, Katie D. Vo, Juergen Reichenbach, Mark Haacke, Daniel K. Kido, Benjamin C.P. Lee, MR high-resolution blood oxygenation level-dependent venography of occult (low-flow) vascular lesions. American Journal of Neuroradiology. ,vol. 20, pp. 1239- 1242 ,(1999)
Swadeshmukul Santra, Peng Zhang, Kemin Wang, Rovelyn Tapec, Weihong Tan, Conjugation of biomolecules with luminophore-doped silica nanoparticles for photostable biomarkers. Analytical Chemistry. ,vol. 73, pp. 4988- 4993 ,(2001) , 10.1021/AC010406+
P Li, J-F Zhang, X-D Xia, D-J Su, B-L Liu, D-L Zhao, Y Liu, D-H Zhao, Serial evaluation of high-resolution CT findings in patients with pneumonia in novel swine-origin influenza A (H1N1) virus infection. British Journal of Radiology. ,vol. 85, pp. 729- 735 ,(2012) , 10.1259/BJR/85580974
Vivek Sehgal, Zachary Delproposto, Djamel Haddar, E. Mark Haacke, Andrew E. Sloan, Lucia J. Zamorano, Geoffery Barger, Jiani Hu, Yingbiao Xu, Karthik Praveen Prabhakaran, Ilaya R. Elangovan, Jaladhar Neelavalli, Jürgen R. Reichenbach, Susceptibility-weighted imaging to visualize blood products and improve tumor contrast in the study of brain masses. Journal of Magnetic Resonance Imaging. ,vol. 24, pp. 41- 51 ,(2006) , 10.1002/JMRI.20598
Claire Corot, Philippe Robert, Jean-Marc Idée, Marc Port, RECENT ADVANCES IN IRON OXIDE NANOCRYSTAL TECHNOLOGY FOR MEDICAL IMAGING Advanced Drug Delivery Reviews. ,vol. 58, pp. 1471- 1504 ,(2006) , 10.1016/J.ADDR.2006.09.013