作者: Barbara Blasiak , James Landry , Randy Tyson , Jonathan Sharp , Umar Iqbal
DOI: 10.1016/J.JNEUMETH.2014.01.034
关键词: MRI contrast agent 、 Nuclear magnetic resonance 、 Magnetic resonance imaging 、 Susceptibility weighted imaging 、 Pulse sequence 、 Nuclear medicine 、 Molecular imaging 、 Gadolinium 、 Glioma 、 Surgical planning 、 Medicine
摘要: Abstract Background Glioma is the most common and difficult to treat brain cancer. Despite many efforts treatment, efficacy remains low. As neurosurgical removal standard procedure for glioma, a method, allowing both early detection exact determination of location, size extent tumor, could improve patient's positive response therapy. New method We propose application susceptibility weighted molecular magnetic resonance imaging using, targeted contrast agents, based on superparamagnetic iron oxide nanoparticles, the, glioma rim, namely brain-tumor interface. Iron attached cells increases, differences at boundary between tumor normal tissue, providing opportunity, utilize improved delineation. investigated potential, enhancement tumor-brain contrast, including core rim when using susceptibility, MRI glioma. Results There were significant in contrast-to-noise ratio before, 12 120 min after agent injection gradient echo pulse sequence molecular, core-brain, rim-core rim-brain areas. Comparison with existing methods Currently, used diagnosis non-specific, gadolinium-based T1-weighted enhancement. Susceptibility-weighted magnetic, much less efficient no agents are, used. Conclusion The provided by SWI offers an important new tool for, surgical planning.