Synergy of antiviral actions of TNF and IFN-γ: Evidence for a major role of TNF-induced IFN-β
作者： Thomas K. Hughes , T.Adam Kaspar , Dorian H. Coppenhaver
DOI: 10.1016/0166-3542(88)90010-1
关键词: Interferon inducer 、 Tumor necrosis factor alpha 、 Antibody 、 Biological activity 、 Interferon gamma 、 Blot 、 Vesicular stomatitis virus 、 Cancer research 、 Biology 、 Cell culture 、 Immunology
摘要: Tumor necrosis factor (TNF) potentiates the antiviral activity of interferon-gamma (IFN-gamma) directly and through induction IFN-beta in HEp-2 cells. Antibody to inhibits a large component TNF IFN-gamma synergy immunoreactive can be detected supernatant fluids TNF-treated Furthermore, kinetics development this its susceptibility inhibition by antibody is demonstrated.
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