Probiotics potentiate IL-6 production in IL-1β-treated Caco-2 cells through a heat shock-dependent mechanism

作者: Natasha Reilly , Vitaliy Poylin , Michael Menconi , Andrew Onderdonk , Stig Bengmark

DOI: 10.1152/AJPREGU.00770.2006

关键词: CytokineInterleukinHypotInflammationIntestinal mucosaHeat shock proteinBiologyCaco-2MicrobiologyEnterocyte

摘要: IL-6 may exert anti-inflammatory and protective effects in intestinal mucosa enterocytes. The influence of probiotics on mucosal enterocyte production is not known. We tested the hypot...

参考文章(53)
Steven L. Kunkel, Thomas P. Shanley, Daniel G. Remick, Jami L. Foreback, Peter A. Ward, Thomas R. Ulich, Regulatory effects of interleukin-6 in immunoglobulin G immune-complex-induced lung injury. American Journal of Pathology. ,vol. 151, pp. 193- 203 ,(1997)
Anu Mathew, Sameer K. Mathur, Richard I. Morimoto, Heat Shock Response and Protein Degradation: Regulation of HSF2 by the Ubiquitin-Proteasome Pathway Molecular and Cellular Biology. ,vol. 18, pp. 5091- 5098 ,(1998) , 10.1128/MCB.18.9.5091
Erika Isolauri, Timo Koivula, Pekka Sillanaukee, T Rautanen, Juntunen M, A Human Lactobacillus Strain (Lactobacillus Casei Sp Strain GG) Promotes Recovery From Acute Diarrhea in Children Pediatrics. ,vol. 88, pp. 90- 97 ,(1991)
Fang Yan, D. Brent Polk, Probiotic Bacterium Prevents Cytokine-induced Apoptosis in Intestinal Epithelial Cells Journal of Biological Chemistry. ,vol. 277, pp. 50959- 50965 ,(2002) , 10.1074/JBC.M207050200
Krzysztof Niedzielin, Hubert Kordecki, Bożena Birkenfeld, A controlled, double-blind, randomized study on the efficacy of Lactobacillus plantarum 299V in patients with irritable bowel syndrome European Journal of Gastroenterology & Hepatology. ,vol. 13, pp. 1143- 1147 ,(2001) , 10.1097/00042737-200110000-00004
Dimitris A Papanicolaou, Ronald L Wilder, Stavros C Manolagas, George P Chrousos, The Pathophysiologic Roles of Interleukin-6 in Human Disease Annals of Internal Medicine. ,vol. 128, pp. 127- 137 ,(1998) , 10.7326/0003-4819-128-2-199801150-00009
Z Xing, J Gauldie, G Cox, H Baumann, M Jordana, X F Lei, M K Achong, IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses. Journal of Clinical Investigation. ,vol. 101, pp. 311- 320 ,(1998) , 10.1172/JCI1368
Alexander A. Parikh, M.Ryan Moon, Christine D. Kane, Andrew L. Salzman, Josef E. Fischer, Per-Olof Hasselgren, Interleukin-6 production in human intestinal epithelial cells increases in association with the heat shock response. Journal of Surgical Research. ,vol. 77, pp. 40- 44 ,(1998) , 10.1006/JSRE.1998.5332