Mitochondrial complex III is required for hypoxia-induced ROS production and gene transcription in yeast.
作者： Robert D. Guzy , Matthew M. Mack , Paul T. Schumacker
关键词: Transcription factor 、 Mitochondrial DNA 、 Enzyme 、 Cell biology 、 Gene 、 Reactive oxygen species 、 Molecular biology 、 Hypoxia (medical) 、 Coenzyme Q – cytochrome c reductase 、 Yeast 、 Biology
摘要: To survive, respiring organisms must sense and respond to changes in environmental oxygen levels. Complex III of the mitochondrial electron transport chain (ETC) has been implicated O2 sensing pathway mammals through its ability increase production reactive species (ROS) during hypoxia. The present study tested whether yeast also contributes Strains deficient DNA (ρ0), Rieske iron—sulfur protein (ΔRip1) III, or an enzyme responsible for coenzyme Q biosynthesis (ΔCoq2) were studied determine importance activity transcriptional response Loss function abrogated hypoxia-induced ROS each strain. Northern analysis identified a set genes that are activated by hypoxia wild-type but not ρ0, ΔRip1, ΔCoq2 strains. Yeast lacking transcription factors Yap1p, Mga2p, Msn2p hypoxic activation gene transc...
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