Circannual control of hibernation by HP complex in the brain.
作者： Noriaki Kondo , Tsuneo Sekijima , Jun Kondo , Nobuhiko Takamatsu , Kazuo Tohya
DOI: 10.1016/J.CELL.2006.03.017
关键词: Darkness 、 Circannual rhythm 、 Internal medicine 、 Biology 、 Liver metabolism 、 Endocrinology 、 Hormone 、 Hibernation
摘要: Seasonal hibernation in mammals is under a unique adaptation system that protects organisms from various harmful events, such as lowering of body temperature (Tb), during hibernation. However, the precise factors controlling remain unknown. We have previously demonstrated decrease hibernation-specific protein (HP) complex blood chipmunks Here, HP identified candidate hormone for In kept constant cold and darkness, regulated by an individual free-running circannual rhythm correlates with The level brain increases coincident onset Such regulation proceeds independently Tb changes warmth, decreases only when increased cold. Blocking activity using antibody duration suggest HP, target endogenously generated rhythm, carries hormonal signals essential to brain.
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