Studies in ANF potentiation. Synthesis of rigid bicyclic analogs of cyclopentyl clutaryl derivatives
作者： Samuel Chackalamannil , Yuguang Wang , Martin F. Haslanger
DOI: 10.1016/S0960-894X(00)80606-X
关键词: Chemistry 、 Long-term potentiation 、 Bicyclic molecule 、 Stereochemistry
摘要: Abstract The synthesis of bicyclic NEP inhibitors represented by the structure 3 is described. These compounds were weaker than cycloalkyl glutaryl derivatives 2 . It suggested that minimum energy conformation adopted compound does not correspond to bio-active occupied
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