Effect of ischaemia and reperfusion on the intracellular concentration of taurine and glutamine in the hearts of patients undergoing coronary artery surgery.
作者： M.-S Suleiman , A.C Moffatt , W.C Dihmis , M Caputo , J.A Hutter
DOI: 10.1016/S0005-2736(96)00225-8
关键词: Taurine 、 Metabolism 、 Biochemistry 、 Endocrinology 、 Intracellular 、 Chemistry 、 Glutamine 、 Coronary artery bypass surgery 、 Ischemia 、 Hypothermia 、 Internal medicine 、 Amino acid
摘要: Taurine and glutamine are the most abundant intracellular free amino acids in mammalian hearts where changes their concentrations likely to influence a number of cellular activities. In this study we investigated effects ischaemia reperfusion on taurine patients undergoing . coronary artery bypass surgery using cold crystalloid or blood cardioplegic solutions. Ischaemic arrest 30 min , solution ns 19 decreased mmolrg wet weight .. from 9.8 " 0.8 7.7 0.7, P- 0.05 8.7 0.5 7.2 0.6 After 20 normothermic fall was maintained 7.5 7.4 0.7 for respectively Myocardial ischaemic with 16 did not cause significant tissue glutamine. However, there marked 9.4 6.5 8.0 5.8 0.4 The associated ATP rise lactate. This work demonstrates that irrespective used heart, is which may extent recovery following surgery. largely due efflux whereas both transport metabolism. Ischaemia, hypothermia transmembrane concentration gradients factors responsible acids.
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M S Suleiman, H C Fernando, W C Dihmis, J A Hutter, R A Chapman, A loss of taurine and other amino acids from ventricles of patients undergoing bypass surgery. Heart. ,vol. 69, pp. 241- 245 ,(1993) , 10.1136/HRT.69.3.241
H A Katus, M Schoeppenthau, A Tanzeem, H G Bauer, W Saggau, K W Diederich, S Hagl, W Kuebler, Non-invasive assessment of perioperative myocardial cell damage by circulating cardiac troponin T. Heart. ,vol. 65, pp. 259- 264 ,(1991) , 10.1136/HRT.65.5.259
Mammalian Amino Acid Transport Springer US. ,(1992) , 10.1007/978-1-4899-1161-2
R. A. Chapman, M. S. Suleiman, G. C. Rodrigo, K. K. Minezaki, K. R. Chatamra, C. R. Little, D. K. Mistry, T. J. A. Allen, Intracellular Taurine, Intracellular Sodium and Defense against Cellular Damage Ionic Channels and Effect of Taurine on the Heart. ,vol. 141, pp. 73- 91 ,(1993) , 10.1007/978-1-4615-3074-9_4
R A Chapman, M-S Suleiman, Y E Earm, Taurine and the heart. Cardiovascular Research. ,vol. 27, pp. 358- 363 ,(1993) , 10.1093/CVR/27.3.358
M.-S. Suleiman, G. C Rodrigo, R. A Chapman, Interdependence of intracellular taurine and sodium in guinea pig heart. Cardiovascular Research. ,vol. 26, pp. 897- 905 ,(1992) , 10.1093/CVR/26.9.897
Sudhir K. Bhatnagar, Joseph D. Welty, Abdul Razzak Al Yusuf, Significance of blood taurine levels in patients with first time acute ischaemic cardiac pain International Journal of Cardiology. ,vol. 27, pp. 361- 366 ,(1990) , 10.1016/0167-5273(90)90293-E
M. Wayne Cooper, J. Barry Lombardini, Elevated Blood Taurine Levels After Myocardial Infarction or Cardiovascular Surgery: Is There Any Significance? Advances in Experimental Medicine and Biology. ,vol. 139, pp. 191- 205 ,(1982) , 10.1007/978-1-4757-0402-0_13
J. B. Lombardini, D. L. Bricker, Effects of cardiovascular surgery on blood concentrations of taurine and amino acids. Experimental Biology and Medicine. ,vol. 167, pp. 498- 505 ,(1981) , 10.3181/00379727-167-41204
MARTIN CHANIN, EUGENE ROBERTS, ALFRED GOLDMAN, Influence of Experimental Myocardial Infarction on Free Amino Acids of Dog Heart Circulation Research. ,vol. 4, pp. 713- 717 ,(1956) , 10.1161/01.RES.4.6.713