Nuclease-mediated targeting with large targeting vectors
作者： George D. Yancopoulos , Wojtek Auerbach , Ka-Man Venus Lai , David Frendewey , David M. Valenzuela
DOI:
关键词: Nuclease 、 Homologous recombination 、 Locus (genetics) 、 Genetics 、 Biology
摘要: Compositions and methods are provided for making one or more targeted genetic modifications at a target genomic locus by employing homologous recombination facilitated single double-strand break near the locus. promoting efficiency of between an LTVEC in prokaryotic eukaryotic cells using engineered nucleases also provided.
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