Prophylaxis of diarrhoea in patients submitted to radiotherapeutic treatment on pelvic district: personal experience.

摘要: Diarrhoea is a severe side-effect of radiotherapy on the pelvic area. It due to acute enteric damage. We aimed at determining ability highly concentrated freeze-dried living bacteria compound (VSL/3) reduce these side-effects in 190 patients receiving radio therapy A total 95 received alone and were also administered VSL/3 bags, doses one bag three times day beginning first treatment. The same diet was indicated for both groups. All irradiated 6 7 weeks, with Linac X-6 MV or 15 through box multiportal technique lower limit fields below obturator foramina, upper L5-S1, lateral 1.5 cm beyond innominate hip. radiated dose ranged from 60 to70 Gy daily 180 cGy. Gastroenteric toxicity rated WHO degrees. Two had discontinue treatment enteritis. Toxicity found 52 (50.6%) vs 36 (30.5%) VSL/3. None them radiotherapy. degrees 3 4 28 These preliminary data suggest effectiveness preventing occurrence diarrhoea submitted direct indirect improvement their quality life good tolerance.