Evidence that the Transmission of One Source of Scrapie Agent to Hamsters Involves Separation of Agent Strains from a Mixture
作者： R. H. Kimberlin , Carol A. Walker
DOI: 10.1099/0022-1317-39-3-487
关键词: Experimental model 、 Hamster 、 Single strain 、 Scrapie 、 Serial passage 、 Transmissible mink encephalopathy 、 Incubation period 、 Biology 、 Virology 、 Scrapie agent
摘要: Summary A previous paper (Kimberlin & Walker, 1977) described an experimental model of scrapie in hamsters which the incubation period decreased progressively over first 4 passages before becoming stable at 5th and subsequent passes. Studies have been made some agent strains present brains taken from 2nd, 3rd, 4th 6th hamster The results indicate presence least two 3rd passage level. One these (431K) is highly pathogenic for mice other (263K) has extremely low pathogenicity mice. However only one brain after serial passage. It suggested that ‘adaptation’ to may involve selection, a mixture, single strain hamsters. possibility modification properties on discussed.
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