Insulin-like growth factor I improves cardiovascular function and suppresses apoptosis of cardiomyocytes in dilated cardiomyopathy.
作者： Wen-Lieng Lee , Jaw-Wen Chen , Chih-Tai Ting , Toshiyuki Ishiwata , Shing-Jong Lin
关键词: Stroke volume 、 Internal medicine 、 Dilated cardiomyopathy 、 Cardiology 、 Cardiac output 、 Pulmonary wedge pressure 、 Ventricular remodeling 、 Vascular resistance 、 Heart failure 、 Medicine 、 Cardiac muscle 、 Endocrinology
摘要: To investigate how insulin-like growth factor I (IGF-I) modulates cardiovascular function and myocardial apoptosis in heart failure, the therapeutic effects of IGF-I were determined a canine model dilated cardiomyopathy. The animals paced at 220 beats/min, left ventricular (LV) chamber became after 2 weeks. A subset dogs was treated with sc injections from week 3 to 4. After 4 weeks pacing, untreated developed significant dysfunction. IGF-I-treated showed better cardiac output, stroke volume, LV end-systolic pressure, end-diastolic pressure. Moreover, pulmonary wedge pressure systemic vascular resistance increased group decreased group. treatment associated less thinning wall. Compared controls, muscle cells, which partially suppressed by treatment. The...
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