The THIK and Thin of Microglia Dynamics.
作者： Jennifer Shih , Chris G. Dulla
DOI: 10.1016/J.NEURON.2018.01.002
关键词: Parenchyma 、 Microglia 、 Interleukin-1beta 、 Neuroscience 、 Potassium 、 Chemistry 、 Potassium channel 、 Ramification (botany)
摘要: Madry et al. (2018) show that the two-pore potassium channel THIK-1 is tonically active in microglia and promotes microglial ramification surveillance of brain parenchyma. Interestingly, not essential to damage-induced outgrowth processes but critical IL-1β release.
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