Complement and microglia mediate early synapse loss in Alzheimer mouse models
作者： S. Hong , V. F. Beja-Glasser , B. M. Nfonoyim , A. Frouin , S. Li
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摘要: … Here we show in mouse models that complement and microglia mediate synaptic loss early in AD. C1q, the initiating protein of the classical complement cascade, is increased and …
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Lennart Mucke, Eliezer Masliah, Gui-Qiu Yu, Margaret Mallory, Edward M. Rockenstein, Gwen Tatsuno, Kang Hu, Dora Kholodenko, Kelly Johnson-Wood, Lisa McConlogue, High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation. The Journal of Neuroscience. ,vol. 20, pp. 4050- 4058 ,(2000) , 10.1523/JNEUROSCI.20-11-04050.2000
Tatsuhiko Ebihara, Izumi Kawabata, Shinichi Usui, Kenji Sobue, Shigeo Okabe, Synchronized Formation and Remodeling of Postsynaptic Densities: Long-Term Visualization of Hippocampal Neurons Expressing Postsynaptic Density Proteins Tagged with Green Fluorescent Protein The Journal of Neuroscience. ,vol. 23, pp. 2170- 2181 ,(2003) , 10.1523/JNEUROSCI.23-06-02170.2003
T. Kim, G. S. Vidal, M. Djurisic, C. M. William, M. E. Birnbaum, K. C. Garcia, B. T. Hyman, C. J. Shatz, Human LilrB2 is a β-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model. Science. ,vol. 341, pp. 1399- 1404 ,(2013) , 10.1126/SCIENCE.1242077
Dorothy P. Schafer, Emily K. Lehrman, Christopher T. Heller, Beth Stevens, An engulfment assay: a protocol to assess interactions between CNS phagocytes and neurons. Journal of Visualized Experiments. ,(2014) , 10.3791/51482
Robert D. Terry, Eliezer Masliah, David P. Salmon, Nelson Butters, Richard DeTeresa, Robert Hill, Lawrence A. Hansen, Robert Katzman, Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Annals of Neurology. ,vol. 30, pp. 572- 580 ,(1991) , 10.1002/ANA.410300410
Marie E. Benoit, Michael X. Hernandez, Minhan L. Dinh, Francisca Benavente, Osvaldo Vasquez, Andrea J. Tenner, C1q-induced LRP1B and GPR6 Proteins Expressed Early in Alzheimer Disease Mouse Models, Are Essential for the C1q-mediated Protection against Amyloid-β Neurotoxicity Journal of Biological Chemistry. ,vol. 288, pp. 654- 665 ,(2013) , 10.1074/JBC.M112.400168
M. R. Wessels, P. Butko, M. Ma, H. B. Warren, A. L. Lage, M. C. Carroll, Studies of group B streptococcal infection in mice deficient in complement component C3 or C4 demonstrate an essential role for complement in both innate and acquired immunity Proceedings of the National Academy of Sciences of the United States of America. ,vol. 92, pp. 11490- 11494 ,(1995) , 10.1073/PNAS.92.25.11490
S. W. Scheff, D. A. Price, F. A. Schmitt, S. T. DeKosky, E. J. Mufson, Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment Neurology. ,vol. 68, pp. 1501- 1508 ,(2007) , 10.1212/01.WNL.0000260698.46517.8F
A. H. Stephan, D. V. Madison, J. M. Mateos, D. A. Fraser, E. A. Lovelett, L. Coutellier, L. Kim, H.-H. Tsai, E. J. Huang, D. H. Rowitch, D. S. Berns, A. J. Tenner, M. Shamloo, B. A. Barres, A dramatic increase of C1q protein in the CNS during normal aging. The Journal of Neuroscience. ,vol. 33, pp. 13460- 13474 ,(2013) , 10.1523/JNEUROSCI.1333-13.2013
Dorothy P. Schafer, Emily K. Lehrman, Amanda G. Kautzman, Ryuta Koyama, Alan R. Mardinly, Ryo Yamasaki, Richard M. Ransohoff, Michael E. Greenberg, Ben A. Barres, Beth Stevens, Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner. Neuron. ,vol. 74, pp. 691- 705 ,(2012) , 10.1016/J.NEURON.2012.03.026