Early introduction of root vegetables in infancy associated with advanced ß‐cell autoimmunity in young children with human leukocyte antigen‐conferred susceptibility to Type 1 diabetes

摘要: Diabet. Med. 28, 965–971 (2011) Abstract Aims  Early introduction of supplementary foods has been implicated to play a role in the development s-cell autoimmunity. We set out study effects breastfeeding and age at on autoimmunity. Methods  A prospective birth cohort 6069 infants with HLA-DQB-conferred susceptibility Type 1 diabetes was recruited between 1996 2004. Antibodies against islet cells, insulin, glutamate dehydroxylase antigen 2 were measured 3- 12-month intervals. The families recorded home new and, for each visit, completed structured dietary questionnaire. endpoint repeated positivity cell antibodies plus least one other antibody and/or clinical (n = 265). Results  root vegetables (by 4 months) related increased risk developing [hazard ratio (95% CI) earliest third 1.75 (1.11–2.75) middle 1.79 (1.22–2.62) compared last (> 4 months), likelihood test P = 0.006], independently several putative socio-demographic perinatal confounding factors. Introducing wheat, rye, oats barley cereals (P = 0.013) egg (P = 0.031) early an endpoint, but only during first 3 years life. Conclusions  infancy is associated autoimmunity among Finnish children genetic diabetes.