Molecular pathology of non-small cell lung cancer
作者： David A. Dorward , Kathy Walsh , Anca Oniscu , William A. Wallace
DOI: 10.1016/J.MPDHP.2017.08.002
关键词: Cancer cell 、 Intensive care medicine 、 PD-L1 、 Companion diagnostic 、 Molecular pathology 、 Adenocarcinoma 、 Medicine 、 Lung cancer 、 Pathology 、 ROS1 、 Non small cell
摘要: Abstract Our increasing understanding of the molecular pathogenesis non-small cell lung cancer (NSCLC), particularly adenocarcinomas, has opened door to ‘personalised medicine' and advent new therapeutic strategies. Over last few years drugs, or classes have been licensed entered clinical practice for use in advanced NSCLC. The activity these drugs is dependent on presence specific protein changes cells which are usually identified using ‘companion diagnostic tests' specifically designed this purpose. Pathologists Pathology Departments had forge links with Clinical Scientists order facilitate additional investigations the, often limited, tissue obtained diagnosis. This collaboration plays a critical role providing link that allows integration traditional morphological diagnosis results diagnostic' tests guide patient management.
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