Synthetic Opioid Use and Common Injection-associated Viruses: Expanding the Translational Research Agenda.

摘要: The US is in the midst of a major epidemic opioid addiction and related comorbidities. People with use disorder (OUD) are at significant risk for transmission several blood-borne pathogens including human immunodeficiency virus (HIV), hepatitis B (HBV), C (HCV). Commonly abused opioids their receptors promote viral replication virus-mediated pathology. However, most studies demonstrating an adverse effect drugs abuse have been conducted vitro, specific effects synthetic on poorly characterized, evaluation opioid-virus interactions clinically relevant populations rare. Rigorous characterization among opioids, host cells, common injection-associated infections will require interdisciplinary research approach translational humans. Such promises to improve clinical management paradigms difficult-to-treat populations, facilitate rational public health policies given severely strained resources, reveal additional pathways novel target-specific therapeutic interventions. This mini-review examines published literature HIV, HBV, HCV pathogenesis proposes series scientific questions considerations establish agenda focused interactions.