Placebo, Double-Blind Evaluation of Long-Term Naltrexone Treatment Effects for Adults with Mental Retardation and Self-Injury
作者： James W. Bodfish , William R. McCuller , James M. Madison , Martisa Register , Richard B. Mailman
关键词: Psychology 、 Double blind 、 Dose level 、 Placebo 、 Stereotypy (non-human) 、 Clinical psychology 、 Anesthesia 、 Active metabolite 、 Statistical analysis 、 Positive response 、 Naltrexone
摘要: This study evaluated the effects of naltrexone treatment for adults with mental retardation and self-injury across, a selection dose levels, target behaviors, subjects phase durations. Statistical analysis group results revealed significant reduction in rate during treatment. However, single-subject data indicated that only two nine assessed demonstrated maintained suppression associated The positive response these occurred at higher level (100 mg/day) appeared to be related increased bioavailability 6-beta-naltrexol, active metabolite naltrexone. Four naltrexone-related reductions stereotypy, one subject increases adaptive material interaction. Given wealth previous research on self-injury, present findings are discussed relation those studies have found more results.
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sci-hub.se 参考文章(15)
M Campbell, A M Small, L M Tesch, P Adams, E L Curren, Naltrexone in infantile autism. Psychopharmacology Bulletin. ,vol. 24, pp. 135- 139 ,(1988)
G Zingarelli, G Ellman, A Chicz-DeMet, A Hom, S Heidorn, M Wymore, Clinical effects of naltrexone on autistic behavior. American Journal on Mental Retardation. ,vol. 97, pp. 57- 63 ,(1992)
Curt A. Sandman, Jennifer L. Barron, Howard Colman, An orally administered opiate blocker, naltrexone, attenuates self-injurious behavior American Journal on Mental Retardation. ,vol. 95, pp. 93- 102 ,(1990)
Carl Feinstein, Rowland P. Barrett, William T. Hole, Effects of naloxone and naltrexone on self-injury: a double-blind, placebo-controlled analysis. American Journal on Mental Retardation. ,vol. 93, pp. 644- 651 ,(1989)
Curt A. Sandman, Purna C. Datta, Jennifer Barron, Fred K. Hoehler, Charles Williams, James M. Swanson, Naloxone attenuates self-abusive behavior in developmentally disabled clients Applied Research in Mental Retardation. ,vol. 4, pp. 5- 11 ,(1983) , 10.1016/S0270-3092(83)80014-9
R. Sandyk, Naloxone abolishes self‐injuring in a mentally retarded child Annals of Neurology. ,vol. 17, pp. 520- 520 ,(1985) , 10.1002/ANA.410170521
Edward R. Ritvo, Increased Blood Serotonin and Platelets in Early Infantile Autism Archives of General Psychiatry. ,vol. 23, pp. 566- 572 ,(1970) , 10.1001/ARCHPSYC.1970.01750060086009
Ludwik Szymanski, Jurgen Kedesdy, Steven Sulkes, Ann Cutler, Paula Stevens-Our, Naltrexone in treatment of self injurious behavior: a clinical study. Research in Developmental Disabilities. ,vol. 8, pp. 179- 190 ,(1987) , 10.1016/0891-4222(87)90002-3
Curt A. Sandman, B‐endorphin disregulation in autistic and self‐injurious behavior: A neurodevelopmental hypothesis Synapse. ,vol. 2, pp. 193- 199 ,(1988) , 10.1002/SYN.890020304
Barbara H. Herman, M. Kathryn Hammock, Ann Arthur-Smith, Bs, James Egan, Irene Chatoor, Alisa Werner, Nathaniel Zelnik, Naltrexone decreases self‐injurious behavior Annals of Neurology. ,vol. 22, pp. 550- 552 ,(1987) , 10.1002/ANA.410220419