Synthesis, antibacterial, antifungal and anti-HIV evaluation of Schiff and Mannich bases of isatin derivatives with 3-amino-2-methylmercapto quinazolin-4(3H)-one.

摘要: Abstract Isatin (Indole 2,3-dione), its 5-chloro and 5-bromo derivatives were added to 3-amino-2-methylmercapto quinazolin-4(3H)-one form Schiff bases the N-Mannich of these compounds synthesized by reacting with formaldehyde several secondary amines. Their chemical structures have been confirmed means their IR, 1 H -NMR data elemental analysis. Investigation antimicrobial activity was done an agar dilution method against 26 pathogenic bacteria, 8 fungi anti-HIV replication HIV-1 (III B) in MT-4 cells. Among tested 5-chloro-3-(3′,4′-dihydro-2′-methylmercapto-4′-oxoquinazolin-3′-yl)-1-morpholino methyl imino isatin most active agent.