Antiproliferative Effect and the Isolated Compounds of Pouzolzia indica
作者： Chanyapat Sangsuwon , Weena Jiratchariyakul , Yaowalak U-pratya , Tanawan Kummalue
DOI: 10.1155/2013/342352
关键词: Scopoletin 、 Pouzolzia 、 Cell culture 、 Glycosphingolipid 、 Methyl caffeate 、 Chemistry 、 Fractionation 、 Glucoside 、 Friedelin 、 Traditional medicine
摘要: Previous report showed the high potent antiproliferative effect of methanolic part extracted from aerial parts Pouzolzia indica on NB4 and HT93A acute leukemic cell lines with IC50 values 28.5 49.8 μg/mL, respectively. The bioassay-guided fractionation gave 5 fractions, that is, FFI–FFV. FFII, FFIII, FFIV inhibited above 15.1 (FFII), 14.4 (FFIII), 32.1 (FFIV), 31.0 9.7 10.5 (FFIV) μg/mL, compounds in these fractions were isolated using chromatographic technique. FFII contained friedelin 1, 28-hydroxy-3-friedelanone 2, 7-methoxy-coumarin 3. FFIII 6, 7-dimethoxy-coumarin 4, scopoletin 5, methyl caffeate 6. sitosteryl glucoside 7 a supposed glycosphingolipid 8. chemical structures elucidated by spectroscopic methods.
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