Endothelium-dependent relaxation and L-arginine metabolism in genetic hypertension.
作者： L Lee , R C Webb
关键词: Medicine 、 Aorta 、 Vasodilation 、 Acetylcholine 、 Contraction (grammar) 、 Internal medicine 、 Arginine 、 Endocrinology 、 Dilator 、 Phenylephrine 、 Omega-N-Methylarginine
摘要: This study characterizes the effects of L-arginine and NG-monomethyl on dilator responsiveness vascular tissue from Wistar-Kyoto rats stroke-prone spontaneously hypertensive rats. Rings abdominal aorta were suspended in baths for measurement isometric force. After contraction induced by phenylephrine, cumulative addition acetylcholine, L-arginine, or A23187 to muscle bath caused a similar relaxation aortic rings both animal groups. To test hypothesis that arginine metabolism is altered hypertension, incubated with L-arginine. (10-300 microM) did not affect contractile responses phenylephrine (10(-10) 10(-4) M) either group (EC50, 10(-7) M). Exposure resulted greater inhibition response acetylcholine 10(-6) animals. (300 complete hypertension group. Incubation (10-100 overcame acetylcholine-induced produced ring segments attenuated 3 x L-Arginine-induced reversal inhibitory effect was between groups.(ABSTRACT TRUNCATED AT 250 WORDS)
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